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Can AI agents and the API use CME data?

No. CME's license does not allow CME market data through the API, MCP or AI agents. An agent can still act on a CME chart, such as drawing on it.

No. CME Group's data license does not allow CME market data to leave the chart through the API, MCP or an AI agent. An agent connected to your chart can still act on a CME chart, for example draw on it, but it cannot read CME prices, candles or depth.

The rule covers CME data only. The Data API reference lists what the API serves, and Is there an API key? explains how to get a key.